relationship between xpd lys 751 gln polymorphism and colorectal cancer risk: a case-control study in a population-based study

this study has examined the relationship between the xpd lys 751 gln polymorphism and colorectal cancer in 88 patients and their 88 age and sex-matched controls. genomic dna from peripheral whole blood was extracted using standard method to determine the genotype of subjects with rflp-pcr analysis. although this study shows cancer patients harbor more heterozygous genotype (xpd lys 751 gln) (or=1.33, ci: 0.679-2.620 and less wild genotype (lys751 lys) compare to control group. however, it is not statistically significant (p = 0.406). furthermore, colorectal cancer was less common in individuals with recessive homozygous genotype (or=0.097, ci: 0.032-0.297; p= 00.000). notably, in our study colorectal cancer was more frequent in male gender, elder people compared younger people and individuals with positive colorectal cancer in their first relatives (or=4.5; ci= 2.010-10.044, p=0.000).